Molecular Diagnostics

BCR/ABL Qualitative or Quantitative (Blood, Bone Marrow)

May be indicated in chronic myelogenous leukemia (CML) and Philadelphia chromosome positive acute lymphocytic leukemia (ALL)

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JAK2 V617F Mutation Analysis (Blood, Bone Marrow)

May be indicated in myeloproliferative disorders (including polycythemia vera, essential thrombocythemia and idiopathic myelofibrosis) and CML

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NPM1 Mutation Analysis (Blood, Bone Marrow)

May be indicated in actue myeloid leukemia (AML)

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Bone Marrow Engraftment Analysis (Blood, Bone Marrow) 

This test utilizes short tandem repeat PCR in order to gauge the percentage of recipient vs. donor cells in blood or bone marrow following hematopoietic stem cell transplantation.  Prior to performing post-transplant analysis, testing of recipient and donor cells by the laboratory is necessary.  The laboratory performs testing on both the unfractionated specimen and also on separated CD3(+) cells.

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Factor V Leiden/Prothrombin G20210A Mutation Testing (Blood)

May be indicated in venous thrombosis and other coagulopathies.

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T & B Cell Clonality

Nucleic acid extraction, multiple primer sets amplification, capillary gel electrophoresis, and pathologist’s interpretation. May be indicated in B-cell and/or T-cell neoplasms.

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PML-Rara

Nucleic acid extraction, reverse transcription, multiple primer sets amplification, gel electrophoresis, and pathologist’s interpretation. May be indicated in acute promyelocytic leukemia (APL/PML/M3).

For more details and ordering, please click here.