5841 S. Maryland Ave.
MC 1089, Room N-316A
Chicago, IL 60637
Y. Lynn Wang, MD, PhD, is a professor and the Founding Director of the Genomic and Molecular Pathology Division at the University of Chicago Medicine.
Dr. Wang is also the principal investigator of several translational research projects on aberrant signal transduction pathways in B-cell lymphoma and leukemia. The laboratory is one of the first to identify B-cell receptor signaling (BCR) as a relevant pathway to target in B-cell malignancies. Using inhibitors of LYN, SYK and BTK, the lab has demonstrated the critical role of BCR in lymphoma cell proliferation and survival in the context of diffuse large B cell lymphoma (DLBCL), CLL and mantle cell lymphoma. Moreover, the lab investigates the mechanisms of drug sensitivity versus resistance and identifies potential biomarkers to predict therapeutic responses. Her investigative work has led to the first identification of BTKC481S mutation in CLL that confers ibrutinib resistance (N Engl J Med. 370: 2352-4. 2014).
Extramurally, Dr. Wang was a member of the International BCR-ABL RQ-PCR Standardization Group whose 5-year work has resulted in the establishment of the first WHO International Genetic Reference Panel for quantification of BCR-ABL in CML monitoring. Dr. Wang is a well accomplished investigator who has authored or co-authored 60 original scientific publications. She has given 69 invited oral presentations outside her institution. She reviews manuscripts for many professional journals including Blood, Leukemia, Cancer Cell and Science Translational Medicine.
Dr. Wang received her MD from Beijing Medical University in 1988 (conferred to a US MD degree in 2002) and her PhD from Brandeis University in 1996. She completed her Clinical Pathology residency, Clinical Molecular Pathology fellowship and postdoctoral research training at the University of Pennsylvania. She is board-certified in Clinical Pathology and Molecular Genetic Pathology. Before joining the faculty of the University of Chicago, she directed the Molecular Hematopathology Laboratory and her lymphoma research laboratory at Weill Cornell Medical College from 2002 to 2013.